Diagnosing cellular defects in an unexplained case of total fertilization failure.

Natural conception following total fertilization failure with intracytoplasmic sperm injection in a couple with unexplained infertility: a case report.

With the introduction of intracytoplasmic sperm injection (ICSI), couples with severe male factor infertility have been able to achieve fertilization and clinical pregnancy rates comparable to other in vitro fertilization patients. However, despite the utilization of microsurgical sperm injection techniques, failure of fertilization still occurs in a few patients. How such fertilization failure...

Comparative study of intracytoplasmic sperm injection and in vitro fertilization with high insemination concentration in sibling oocytes in the treatment of unexplained infertility.

INTRODUCTION Some unexplained infertile couples may have fertilization failure; the in vitro fertilization (IVF) with high insemination concentration (HIC) and intracytoplasmic sperm injection (ICSI) were reported to give better fertilization rate when compared to standard IVF procedure. OBJECTIVE To compare the fertilization rate, abnormal fertilization rate, total fertilization failure rate...

Easily decapitated spermatozoa defect: a possible cause of unexplained infertility.

We report the first 16 cases of a new sperm abnormality which we call 'easily decapitated spermatozoa defect'. This was discovered during intracytoplasmic sperm injection (ICSI) in couples with unexplained infertility. Semen analysis was normal, but minimal micromanipulation for ICSI resulted in decapitation of the spermatozoon during immobilization. For some oocytes the head and tail were inje...

P-205: Analysis of Mlh3 C2531T Polymorphism in Iranian Women with Unexplained Infertility

Background: Infertility is increasingly recognized as a major health problem. Meiotic genes are very important candidates for genes contributing to female and male infertility. Mammalian MutL homologues have dual roles in DNA mismatch repair (MMR) after replication errors and meiotic reciprocal recombination. There are four MutL homologues in eukaryotes that mutations of three of them (Mlh1, Ml...

P-226: Association of ?-Defensin 126 Gene Alteration with Intra Cytoplasmic Sperm Injection and In Vitro Fertilization Outcome in Unexplained Infertile Men